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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDX3X All Species: 26.97
Human Site: S605 Identified Species: 42.38
UniProt: O00571 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00571 NP_001347.3 662 73243 S605 G A R D Y R Q S S G A S S S S
Chimpanzee Pan troglodytes Q6GVM6 660 73172 S603 G A R D Y R Q S S G S S S S G
Rhesus Macaque Macaca mulatta XP_001095294 910 100218 Q854 F G A R D Y R Q S S G A S S S
Dog Lupus familis XP_861268 662 73195 S605 G A R D Y R Q S S G A S S S S
Cat Felis silvestris
Mouse Mus musculus Q62167 662 73083 S605 G A R D Y R Q S S G A S S S S
Rat Rattus norvegicus NP_001102328 659 72976 S602 G A R D Y R Q S S G A S S S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512924 651 71975 S591 G A R D Y R Q S S G A S S S S
Chicken Gallus gallus NP_001025971 651 72031 Y594 G G F G A R D Y R T S S G A G
Frog Xenopus laevis P24346 697 77284 K640 F S G G F G A K D Y R Q S S G
Zebra Danio Brachydanio rerio NP_571016 688 75828 D631 S G G F G A R D Y R Q N S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VHP0 798 85063 S724 G S R D Y R Q S S G G G G G G
Honey Bee Apis mellifera XP_391829 701 78642 R645 F S G G F G A R D Y R Q Q P S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M2F9 646 69224 G569 R R E S F S R G G G G A D Y Y
Baker's Yeast Sacchar. cerevisiae P24784 617 67899 F561 T R G G G G F F N S R N N G S
Red Bread Mold Neurospora crassa Q9P6U9 688 72037 K617 T Q T A D Y R K F G G S G G G
Conservation
Percent
Protein Identity: 100 91.3 70.1 99.8 N.A. 98.6 95.3 N.A. 95.9 91.2 82.2 76.3 N.A. 51.7 58 N.A. N.A.
Protein Similarity: 100 95.3 70.3 99.8 N.A. 99 97.1 N.A. 97.2 94.7 88 83.8 N.A. 63.4 70 N.A. N.A.
P-Site Identity: 100 86.6 26.6 100 N.A. 100 100 N.A. 100 20 13.3 20 N.A. 60 6.6 N.A. N.A.
P-Site Similarity: 100 93.3 40 100 N.A. 100 100 N.A. 100 33.3 26.6 33.3 N.A. 66.6 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 49.5 49.4 52
Protein Similarity: N.A. N.A. N.A. 64.6 65.2 64.8
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 40 7 7 7 7 14 0 0 0 34 14 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 47 14 0 7 7 14 0 0 0 7 0 0 % D
% Glu: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 20 0 7 7 20 0 7 7 7 0 0 0 0 0 0 % F
% Gly: 54 20 27 27 14 20 0 7 7 60 27 7 20 20 34 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 14 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 7 0 0 14 7 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % P
% Gln: 0 7 0 0 0 0 47 7 0 0 7 14 7 0 0 % Q
% Arg: 7 14 47 7 0 54 27 7 7 7 20 0 0 0 0 % R
% Ser: 7 20 0 7 0 7 0 47 54 14 14 54 60 60 60 % S
% Thr: 14 0 7 0 0 0 0 0 0 7 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 47 14 0 7 7 14 0 0 0 7 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _